Bioactive Small Molecules
Cayman Chemical ANTIBODY ISP-I-28 10mg
An immunosuppressant; increases skin graft survival time in rats at 1, 3, and 10 mg/kg
Medchemexpress LLC Uridine 5'-diphosphate (sodium salt) | 21931-53-3 | 98.0% | 500 MG
Uridine 5'-diphosphate sodium salt is a potent and selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52) and a potent P2Y14 antagonist (pEC50=7.28). This endogenous metabolite catalyzes the glucuronidation of a wide array of substrates and is utilized in nucleic acid (RNA) biosynthesis.
- Potent and selective P2Y6 receptor native agonist.
- Potent P2Y14 antagonist.
- Catalyzes glucuronidation of various substrates.
- Utilized in nucleic acid (RNA) biosynthesis.
Medchemexpress LLC Scopolamine hydrobromide trihydrate | 6533-68-2 | 99.86% | 438.31 | 1 ML
Scopolamine (Hyoscine) hydrobromide trihydrate is a high-affinity muscarinic antagonist that can cross the blood-brain barrier. It competitively antagonizes 5-HT3 receptors with an IC50 of 2.09 μM. This compound induces cognitive and memory deficits in animals and is used in research for preventing postoperative nausea and vomiting, motion sickness, and nervous system diseases.
- High-affinity muscarinic antagonist
- Can cross the blood-brain barrier
- Competitively antagonizes 5-HT3 receptors with an IC50 of 2.09 μM
- Induces cognitive and memory deficits in animals
- Used for preventing postoperative nausea and vomiting
- Used for motion sickness research
- Used for nervous system diseases research
- For research use only
- Can be used to induce memory impairment models
Selleck Chemical LLC Derazantinib(ARQ-087) 2mg 1234356-69-4
Derazantinib(ARQ-087) is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with IC50 values of 1.8 nM for FGFR2, and 4.5 nM for FGFR1 and 3, showing lower potency for FGFR4 (IC50=34 nM). It also inhibits RET, DDR2, PDGFR?, VEGFR and KIT. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Bimiralisib (PQR309) 5mg 1225037-39-7
Bimiralisib (PQR309) is a novel brain-penetrant dual PI3K/mTOR inhibitor with in vitro and in vivo antilymphoma activity. It displays excellent selectivity versus PI3K-related lipid kinases, protein kinases and unrelated targets. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Glucagon HCl 50mg 16941-32-5 H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH
Glucagon HCl stimulates glycogenolysis in the liver, used as the hydrochloride salt as an antihypoglycemic and as an adjunct in gastrointestinal radiography. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC HY-117930 25mg , Danicopan CAS:1903768-17-1 Purity:>98%
HY-117930 25mg Danicopan CAS: 1903768-17-1 Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Cy5-PEG5-azide bromide | 00-00-0 | 98.8% | 851.91 g/mol | C44H63BrN6O6 | 5 MG
Cy5-PEG5-azide bromide is a PEG-based Cy5 fluorescent linker bearing an azide functional group and a bromide terminus, designed for bioconjugation via click chemistry. It is intended for labeling biomolecules, preparing linkers, and fluorescence-based assays where a water-soluble spacer and reactive azide are required.
- Contains an azide functional group for copper-catalyzed and strain-promoted click reactions.
- PEG5 spacer improves solubility and reduces steric hindrance.
- Cy5 fluorophore enables near-infrared fluorescence labeling for imaging applications.
- High reported purity supports analytical and preparative use.
- Available in small milligram quantities suitable for reaction-scale labeling.
Medchemexpress LLC RBP4 inhibitor 1 | 1198180-03-8 | 99.7% | 357.25 | C14H13F6NO3 | 5 MG
RBP4 inhibitor 1 is a potent, orally active retinol-binding protein 4 (RBP4) inhibitor reported to reduce blood RBP4 levels in vivo. It exhibits low-nanomolar activity against human RBP4 and is supplied as a high-purity research compound.
- Potent RBP4 inhibition: IC50 28 nM (human), 110 nM (mouse).
- High purity: 99.74%.
- Appearance: white to off-white solid.
- Molecular weight: 357.25 g/mol.
- Chemical formula: C14H13F6NO3.
- SMILES string provided for structural reference.
- Storage: powder at -20°C (stable for 3 years); in solvent -80°C for 6 months, -20°C for 1 month.
- Available in small research pack sizes and DMSO solutions for screening.
Medchemexpress LLC Sulfo-NHS-acetate sodium | 221222-61-3 | MFCD01861959 | 95.0% | 259.17 g·mol⁻¹ | C6H6NNaO7S | 5 MG
Sulfo-NHS-Acetate sodium is a water-soluble N-hydroxysuccinimide (NHS) ester used to acetylate primary amines and as a building block in PROTAC linker synthesis. Supplied as the sodium sulfonate salt for improved aqueous solubility, it enables efficient amine modification under mild, aqueous conditions for biochemical and chemical biology research.
- Water-soluble sodium sulfonate form for improved handling in aqueous buffers.
- Reacts with primary amines to introduce acetyl groups under mild conditions.
- Suitable for bioconjugation, protein modification, and linker synthesis.
- High purity appropriate for research applications.
- Available in small pack sizes for low-scale synthesis and labeling studies.
Medchemexpress LLC Desisopropyl atrazine-d5 | 1189961-78-1 | 98.0% | 178.63 | C5H3D5ClN5 | 5 MG
Desisopropylatrazine-d5 is the deuterium-labeled isotopologue of desisopropylatrazine (CAS 1189961-78-1), provided as an analytical reference standard for research and isotope-dilution mass spectrometry. Molecular formula C5H3D5ClN5; molecular weight 178.63 g·mol⁻¹. Chemical purity is typically reported around 98%.
- Isotopically labeled (d5) analog for use as an internal standard.
- Suitable for isotope-dilution quantitation by GC-MS or LC-MS.
- Chemical purity approximately 98% for analytical use.
- Molecular formula C5H3D5ClN5 and molecular weight 178.63 g·mol⁻¹.
- Supplied as a neat solid in small research quantities.
- For research use only; not intended for human or clinical use.
Medchemexpress LLC Biotin-labeled ODN 1826 sodium | 00-00-0 | 95.9% | 6,824 g/mol | 5'-tccatgacgttcctgacgtt-Biotin (20 mer) | 5 MG
Biotin-labeled ODN 1826 sodium is a biotin-conjugated class B CpG oligodeoxynucleotide (20-mer) that functions as a TLR9 agonist. Supplied as a solid for use in cellular uptake and localization studies, the product is intended for detection with biotin/streptavidin systems and microscopy-based assays.
Medchemexpress LLC (1r)-deruxtecan | 2270986-87-1 | 99.3% | 1,034.05 g·mol⁻¹ | C52H56FN9O13 | 5 MG
(1R)-Deruxtecan is a drug-linker conjugate intended for use in antibody-drug conjugate (ADC) research. It is supplied as a small-scale research reagent with supporting analytical documentation and is not for human or clinical use.
- Drug-linker conjugate suitable for ADC development.
- High purity (~99.3%) as indicated by analytical testing.
- Available in small research pack sizes (5 mg).
- Soluble in DMSO for preparation of stock solutions.
- Provided with COA, SDS, and supporting analytical data when available.
- Intended for research use only, not for human use.
Medchemexpress LLC Azido-PEG16-NHS ester | 00-00-0 | 99.9% | 917.00 | C39H72N4O20 | 5 MG
Azido-PEG16-NHS ester is a PEG-based N-hydroxysuccinimide (NHS) ester linker bearing an azide functional group for click chemistry and bioconjugation. It is used to introduce azide handles or to couple with primary amines when building conjugates, linkers, and PROTAC components in chemical biology workflows.
- Contains an azide group for CuAAC and SPAAC click reactions.
- NHS ester enables rapid coupling to primary amines.
- PEG16 spacer provides hydrophilicity and conformational flexibility.
- High purity suitable for analytical and preparative use.
- Highly soluble in DMSO for concentrated stock solutions.
- Stable when stored protected from light at 4°C; in solvent store at -80°C or -20°C.
Medchemexpress LLC HG-10-102-01 | 1351758-81-0 | MFCD28160565 | 99.6% | 377.83 g/mol | C17H20ClN5O3 | 5 MG
HG-10-102-01 is a potent, selective, brain-penetrant small-molecule inhibitor of leucine-rich repeat kinase 2 (LRRK2) for research use. It exhibits low-nanomolar activity against wild-type and G2019S mutant LRRK2 and is supplied as a high-purity solid suitable for cellular and in vivo studies.
- Potent LRRK2 inhibition at low nanomolar concentrations.
- Brain-penetrant profile suitable for central nervous system studies.
- Active against both wild-type and G2019S mutant forms of LRRK2.
- High chemical purity appropriate for research applications.
- Supplied in milligram-scale quantities for laboratory use.
- Molecular formula C17H20ClN5O3; molecular weight 377.83 g/mol.