Bioactive Small Molecules
Medchemexpress LLC Gpat-In-1 | 1204347-51-2 | C21H26ClNO4S | 25 MG
GPAT-IN-1 is a glycerol-3-phosphate acyltransferase (GPAT) inhibitor with an IC50 value of 8.9 μM, making it suitable for research into obesity. It appears as a white to off-white solid with a molecular weight of 423.95 and a purity of 97.12%.
Medchemexpress LLC Eugenin | 480-34-2 | 99.97% | 206.20 | 1 ML
Eugenin is a chromone isolated from Formosan Peucedanum japonicum that exhibits an effective antiplatelet aggregation effect. It also demonstrates certain cytotoxicity against tumor cells.
- Effective antiplatelet aggregation agent
- Exhibits cytotoxicity against tumor cells
- Isolated from Formosan Peucedanum japonicum
Medchemexpress LLC AZD-6280 | 942436-93-3 | 99.1% | 366.41 | 1 ML
AZD-6280 is a selective GABAA(α2/3) receptor modulator, used for treatment of generalized anxiety disorder. It offers the following key features and benefits:
- Selective GABAA(α2/3) receptor modulator
- Used for treatment of generalized anxiety disorder
Cayman Chemical 4-methoxy-5-Hydroxycanthin-6-one, Purity: ≥98%, CAS: 18110-86-6, 5 mg
An alkaloid with anti-inflammatory activity; reduces LPS-induced TNF-α release from, and NO production in, RAW 264.7 macrophages at 10, 30, and 100 µM; reduces paw swelling in a rat model of CFA-induced arthritis at 9 and 27 mg/kg; reduces colonic inflammatory cytokine levels and maintains mucosal barrier function in a mouse model of DSS-induced colitis from 25-100 mg/kg
Medchemexpress LLC 5-Ethynylindane | 132464-86-9 | 99.1% | 142.20 | 500 MG
5-Ethynylindane is a laboratory chemical intended for research use only. This product is for experienced personnel and must be handled by suitably qualified scientists in appropriately equipped facilities. It appears as a yellow to orange liquid and has been tested to comply with specifications. It has not been fully validated for medical applications.
- For research use only
- Handled by qualified personnel
- Tested to comply with specifications
- Yellow to orange liquid appearance
- Used in laboratory chemicals and substance manufacturing
Medchemexpress LLC (Rac)-Lisaftoclax | 2651980-10-6 | 98.22% | 1 MG
(Rac)-Lisaftoclax ((Rac)-APG-2575) is a Bcl-2 inhibitor that can be used for hematologic malignancy research. This product is provided as a powder and should be stored at -20°C for up to 3 years or 4°C for 2 years for optimal stability. Short-term shipping at room temperature is acceptable if the duration is less than 2 weeks. The product container should be kept tightly sealed in a cool, well-ventilated area, away from direct sunlight and sources of ignition.
- Bcl-2 inhibitor for hematologic malignancy research
- Provided as a high-purity powder
- Long-term storage stability at -20°C or 4°C
- Shipped safely at room temperature for durations under two weeks
- Requires storage in a sealed container in a cool, well-ventilated area
Cayman Chemical INNO-8875, Purity: ≥95%, CAS: 871108-05-3, 5 mg
An adenosine A1 receptor agonist; binds to adenosine A1 receptors (Ki = 0.97 nM) and is >10,000-fold selective for adenosine A1 over A2 receptors; topical application reduces intraocular pressure in a rabbit model of ocular hypertension at 25 µg/eye; decreases atrial refractoriness and heart rate, as well as slows atrioventricuolar nodal conduction, in anesthetized rats from 1-50 µg/kg
Medchemexpress LLC Umbralisib | 1532533-67-7 | 98.9% | 50 MG
Umbralisib is an orally active, selective inhibitor of PI3Kδ and casein kinase-1-ε used in preclinical research on B-cell malignancies and kinase signaling. Supplied as a white to off-white solid with high purity for laboratory assays.
- Selective PI3Kδ and CK1ε inhibition for oncology research.
- High purity (≈98.9%) solid suitable for in vitro and preclinical studies.
- Recommended storage: powder stable at -20°C for long-term storage.
- Supplied in a 50 mg package for assay development and compound screening.
Medchemexpress LLC HY-123523 5mg Medchemexpress, Enocitabine CAS:55726-47-1 Purity:>98%
Medchemexpress, HY-123523 5mg Enocitabine CAS:55726-47-1 Enocitabine is a nucleoside analog, and is a potent DNA replication inhibitor, and a DNA chain terminator. Enocitabine inhibits the replication of human cytomegalovirus. Enocitabine has antileukemic and antiviral activities[3]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical CDDO-Im, Purity: ≥95%, CAS: 443104-02-7, 1 mg
An activator of Nrf2 signaling; increases the expression of Nrf2 target genes and activates HO-1 in CV-1 cells at 100 nM; binds to PPARγ and PPARα (Kis = 344 and 232 nM, respectively) and induces PPARγ transactivation in SW480 cells; inhibits NOS production in isolated mouse macrophages (IC50 = 0.014 nM); inhibits proliferation of U937 and MCF-7 cells at 300 nM; reduces fatty acid synthesis in LiSa-2 human liposarcoma cells at 100 nM; reduces tumor growth in a B16 murine melanoma model at 50 µg/animal twice per day
TARGETMOL CHEMICALS INC OSMI-1 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor (IC50 2.7 uM). purity: 99%
Cayman Chemical R 1530, Purity: ≥98%, CAS: 882531-87-5, 5 mg
A multi-kinase inhibitor that targets over 20 kinases, including angiogenesis-related receptor tyrosine kinases (Kds = 61, 88, and 15 nM for FGFR1, PDGFRβ, and VEGFR2, respectively); also inhibits FLT1, KIT, PLK4, and RET with Kd values of 9, 26, 11, and 22 nM, respectively
Cayman Chemical (±)-Norepinephrine-d6 (hydrochloride), Purity: ≥99% (deuterated forms d1-d6), CAS: 1219803-04-9, 5 mg
An internal standard for the quantification of norepinephrine by GC- or LC-MS
Medchemexpress LLC AITRL/TNFSF18 Human 10ug
AITRL a type II transmembrane protein is a ligand for glucocorticoid-induced TNFR-related protein (GITR) When AITRL binds to GITR GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions GITR/AITRL interaction plays a role in the pathogenesis of tumor inflammation as well as autoimmune diseases[1] Besides AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1 ICAM-1)[2] AITRL/TNFSF18 Protein Human is a recombinant human AITRL (E74-I198) without tag which is expressed in E coli
Medchemexpress LLC Dasantafil | 569351-91-3 | 98.4% | 522.39 g/mol | C22H28BrN5O5 | 5 MG
Dasantafil (SCH-446132) is a small-molecule phosphodiesterase-5A (PDE5A) inhibitor used in preclinical research of genitourinary disorders, including studies of erectile dysfunction. The compound is supplied as a solid with high chemical purity and includes recommended solubility and storage guidance suitable for in vitro and in vivo formulation.
- High purity: 98.35%.
- Selective PDE5A inhibitor for mechanistic and pharmacology studies.
- Molecular weight 522.39 g/mol.
- Soluble in DMSO (≥100 mg/mL); in vivo formulations yield clear solutions ≥2.5 mg/mL.
- Storage recommendations: sealed, away from moisture; in solvent -80°C (6 months), -20°C (1 month).
- Supplied in small research quantities (for example, 5 mg).